Wnt-3a and Dvl Induce Neurite Retraction by Activating Rho-Associated Kinase
نویسندگان
چکیده
منابع مشابه
Wnt-3a and Dvl induce neurite retraction by activating Rho-associated kinase.
Dvl is a key protein that transmits the Wnt signal to the canonical beta-catenin pathway and the noncanonical planar cell polarity (PCP) pathway. We studied the roles of Rho-associated kinase (Rho-kinase), which is activated by Dvl in the PCP pathway of mammalian cells. The expression of Dvl-1, Wnt-1, or Wnt-3a activated Rho-kinase in COS cells, and this activation was inhibited by the Rho-bind...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2004
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.24.10.4487-4501.2004